HF's DNA model evals: Carbon-Mid-300B nears Evo2 with just 160B training tokens

_lewtun · x · 2026-10-23

Loubna Ben Allal of Hugging Face shared evals comparing the team's new DNA models against Evo2. On pure DNA benchmarks, Carbon-Mid-300B scores 0.83 AUROC on BRCA2 VEP, 0.89 on ClinVar coding and 0.94 on ClinVar non-coding — matching or beating Carbon-3B and Evo2-7B, and far above the Qwen3-14B Instruct baseline (0.45–0.50) after midtraining.

She notes DNA performance isn't saturated yet: the new model was trained on only 160B DNA tokens versus 1T for the previous Carbon model on the same data, hinting the next version will train much longer.

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