Omnii Genome: single generalist model beats AlphaGenome at linking variants to gene activity

BenSiranosian · x · 2026-10-23

Radical Numerics introduced Omnii Genome, built on Omnii-1, bringing multimodal capabilities to generative genomics. A single generalist model outperforms the leading specialized model AlphaGenome at linking genetic changes to gene activity and mapping regulatory interactions — helping make sense of the 98% of the human genome that doesn't code for proteins. Details in their blog post and video.

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