Baker lab's RFD4-Proteina designs binders for phosphoserine and phosphothreonine sites
AllThingsApx · x · 2026-10-21
David Baker's IPD lab extends RFD4-Proteina beyond the canonical 20 amino acids: following their phosphotyrosine binder work, the new workflow designs binders recognizing phosphoserine and phosphothreonine.
The standout result is site selectivity — binders can distinguish adjacent H3pS10 and H3pT11 sites on the histone H3 tail, enabled by a unified latent space. A meaningful step for AI protein design into post-translational modification recognition, a key biomedical use case.
Related event: NVIDIA and Baker Lab Open-Source RFD4-Proteina Protein Design Model(35 posts)→
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