NVIDIA releases RFD4-Proteina: open protein-design model, 13× faster than RFdiffusion3, SOTA on 12+ tasks
AllThingsApx · x · 2026-10-21
- NVIDIA BioNeMo and the University of Washington Institute for Protein Design released RFD4-Proteina, a new open protein-design model.
- Headline numbers: 13× faster generation than RFdiffusion3 at 200 residues, state-of-the-art across 12+ protein design tasks.
- It supports programmable design inputs and test-time compute for harder problems; NVIDIA also published a binder-design tutorial to get started.
Related event: NVIDIA and Baker Lab Open-Source RFD4-Proteina Protein Design Model(35 posts)→
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