NVIDIA and UW release RFD4-Proteina, unifying sequence and all-atom protein design
AllThingsApx · x · 2026-10-21
NVIDIA and the University of Washington's Institute for Protein Design (one year of BakerLab + NVIDIA GenAIR collaboration) present RFD4-Proteina, a BioNeMo open model that unifies protein sequence and all-atom structure generation in a single flow-matching model with an autoencoder encoding each residue's anchor-atom coordinate and chemical identity. It designs in molecular contexts including proteins, small molecules, nucleic acids, glycans, metal ions, and modified residues, reportedly beating all compared methods in silico and in the lab. A free Hugging Face Space is live—no CS degree required.
Related event: NVIDIA and Baker Lab Open-Source RFD4-Proteina Protein Design Model(35 posts)→
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