vLLM + NVIDIA wideEP Co-Design Makes GB300 NVL72 7.2x Better Perf per TCO

woosuk_k · x · 2026-10-15

SemiAnalysis reports that vLLM, Inferact and NVIDIA pushed co-design to the extreme on GB300 NVL72, achieving 7.2x better performance per TCO than other AI chips using a wideEP (wide expert-parallel) inference optimization that exploits the NVL72 backplane. The chart benchmarks DeepSeek V4.1 Flash 552B agentic tokens per $1 TCO vs P90 interactivity: GB300 NVL72 leads B200 (vLLM) by 7.22x and B300 by 3.21x, well ahead of MI325X/MI300X (vLLM). Hourly per-chip TCO listed: H100 $1.17, H200 $1.22, B200 $1.73, GB300 $2.31, MI300X $0.95.

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