CRISPR perturbations in engineered cell states reveal disease biology missed by steady-state maps
anshulkundaje · x · 2026-10-15
New collaborative work with the Norman lab shows that most genes and variants matter somewhere but look silent in any single cell model. By engineering cell states, CRISPR perturbations can expose hidden regulatory states that explain cis- and program-level genetic architecture of complex diseases — biology that steady-state maps miss — and trace how genetic risk reaches disease genes.
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