Deep learning maps low-affinity pioneer binding sites that cooperate to open chromatin
anshulkundaje · x · 2026-10-14
The Zeitlinger Lab uses deep learning to systematically map low-affinity pioneer transcription factor binding sites in mESCs, showing that weak motifs cooperate with strong motifs to open chromatin.
- Addresses the fundamental question of whether weak TF motifs matter
- Accompanied by a preview from Grace Bower
An AI-for-Science case of deep learning uncovering gene regulation mechanisms.
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