Anshul Kundaje: protein localization breaks RNA-only gene regulatory models

anshulkundaje · x · 2026-10-14

Computational biologist Anshul Kundaje argues that RNA alone is the wrong input for 'causal regulatory models': transcription factors only regulate when nuclear, and signaling cascades drastically change protein function and localization—so expression-level models miss the physical, protein-driven reality of gene regulation.

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