Pythia team releases protein-RNA binding atlas preprint probing why the model predicts

anshulkundaje · x · 2026-10-14

Karimzadeh et al. released a bioRxiv preprint presenting Pythia, a structure-aware model plus a high-resolution protein-RNA binding atlas for post-transcriptional regulatory modeling. The team spans UCSF, Arc Institute, Helmholtz Munich and more (including David Kelley and Bo Wang), and aims to understand why the model makes its binding predictions.

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