Joseph Jacks: what AlphaFold and sequence models like ESM fail to capture
JosephJacks_ · x · 2026-10-13
Joseph Jacks reshares his article "Runtime Biology," arguing that sequence models like AlphaFold, ESM, and Evo miss what happens at runtime: living cells acting dynamically in 3D. Quoting Feynman on nature being quantum-mechanical, the piece pushes for simulation beyond sequence. The thread also highlights Manu Prakash's 2020 Gravity Machine, which images cells moving in 3D rather than flattened under a coverslip, showing how new observation methods unlock discoveries.
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