300M lab tests show menopause is a physiological cliff, not a slow slope
MaxUnfried · x · 2026-10-13
A Weizmann Institute team published in Nature Medicine a computational framework, inspired by astronomy, that reconstructs FMP-anchored trajectories from cross-sectional data by removing blurring from variation in final-menstrual-period age.
- Applied to 300M+ lab tests from 1M+ women across two cohorts
- Many body systems (endocrine, skeletal, hepatic, renal, lipid) show a step-like physiological cliff at the final menstrual period
- No such discontinuity exists in men, and findings hold across populations
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