Scientists identify the 'hangry neuron' in fruit flies that turns hunger into aggression

mjdramstead · x · 2026-10-13

A new Nature Communications study identifies a 'hangry neuron' in the Drosophila mushroom body that converts hunger states into graded, nutrient-specific aggression. Dopaminergic inputs bidirectionally tune the neuron's excitability via Dop1R1 and Dop1R2 receptors, which activate intracellular cAMP and calcium pathways respectively. The work reveals an unexpected aggression-modulating role for the mushroom body—traditionally seen as the fly's learning and memory center—and shows how a single neuron integrates distinct dopamine pathways to mediate flexible behavior, a function typically handled by the basal ganglia in mammals.

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