MedGemma 4B runs fully in-browser via WebGPU, paired with AlphaGenome for private DNA explainer
gpt872323 · reddit · 2026-10-13
A developer released AskCyph Health Explorer, a free, no-login educational tool for exploring how single-letter DNA mutations cause disease, alter 3D anatomy, inheritance odds, and treatments.
The architecture splits work between two models:
- Molecular prediction: calls Google DeepMind's AlphaGenome API to predict regulatory variant effects and splicing disruptions (e.g., sickle cell coding change vs. non-coding beta-thalassemia splicing break).
- Local private explainer: MedGemma 1.5 4B (INT4 ONNX, 2.8 GB compressed) runs 100% in-browser via ONNX Runtime Web + WebGPU; all chat and multimodal inspection (X-rays, histology diagrams) stay on-device.
- Deterministic grounding: variant details, OMIM IDs, inheritance modes, and drug approvals come from NCBI ClinVar, openFDA, and ClinicalTrials.gov, injected into the prompt so the local model synthesizes verified facts without hallucinating clinical details.
The author invites others to test WebGPU throughput and share patterns for pairing specialized foundation models with client-side SLMs in sensitive domains.
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