12M single cells, 2,600 people: seminal immune aging paper yields practical blood test
EricTopol · x · 2026-10-12
Eric Topol highlights a newly published seminal study on immune system aging, analyzing over 12 million single cells across 8 cohorts and more than 2,600 individuals aged 18 to 98.
The core finding concerns two states of CD8+ effector-memory T cells: one with GZMB-rich granules and another with GZMK-rich granules, revealing distinct cytotoxic programs that shift with age.
A key output is a practical blood test for immune aging. Topol discusses the paper in depth in his Ground Truths piece "A Tale of Two T cells."
Related event: 12-Million Single-Cell Study Maps Immune Aging(2 posts)→
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