154 drugs with unknown mechanisms of action, including alcohol and anesthesia

francoisfleuret · x · 2026-10-12

François Fleuret drops the Wikipedia category "Drugs with unknown mechanisms of action" in response to Martin Shkreli's claim that "we do know the mechanisms for most drugs." The category lists 154 drugs whose therapeutic mechanism is unknown or unclear—including alcohol, cannabidiol, amantadine, and the entire general anesthetics subcategory (105 entries).

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