We don't even know how Tylenol works: most drugs are 'misaligned', sparked by Tao debate

AntonObukhov1 · x · 2026-10-11

A debate sparked by Terence Tao's comments on drug development: many drugs, including chemotherapy agents, have poorly understood mechanisms of action—we don't even know how Tylenol works, and off-target side effects mean most drugs are arguably 'misaligned'. Anton Obukhov added that the gap between 'it works' and understanding it down to the bits should start being taxed.

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