SpliceAI2 deep dive: splice graphs and DP reconstruct top transcripts for 82% of held-out genes

anshulkundaje · x · 2026-10-10

A technical deep dive on SpliceAI2 explains its transcript prediction and training approach: combining splice graphs, dynamic programming, and long-read RNA-seq to perfectly reconstruct the top transcript for 82% of held-out genes.

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