Kundaje: current experiment designs can't yield virtual cells or causal world models

anshulkundaje · x · 2026-10-06

Continuing his thread on the limits of genomic perturbation models, Anshul Kundaje argues the bigger issue is the data design itself: with current experimental designs and measured inputs, one cannot learn virtual cells, world models, or models that capture biologically causal mechanisms. A notable critique of the current virtual-cell direction in AI for Science.

Related event: Stanford's Kundaje Attacks Single-Cell Foundation Models and 'Virtual Cell' Hype in 12-Tweet Thread(12 posts)→

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