Mitocarta consortium publishes 9 Cell papers, ML remaps mitoproteomes across eukaryotes
anshulkundaje · x · 2026-10-04
Vamsi Mootha's Mitocarta Tree of Life consortium released 9 back-to-back papers (plus 2 perspectives) across the Cell family:
- Mito proteomes characterized across 6 diverse species, from Giardia to Leishmania to Arabidopsis
- Optimized methods for mito enrichment, DIA mass spec, protein correlation profiling, microscopy validation, and cryoEM of native complexes
- Comparative analysis reveals dozens of proteins shared among pathogens but lost in human hosts — "pan-parasite" drug targets
- Data re-trains an ML subcellular localization predictor, predicting mitoproteomes across hundreds of eukaryotes
- Functionally validated Giardia solute carrier discovered; aerobic-to-anaerobic mito rewiring in Acanthamoeba mapped
More from Research
- Researcher to present work on fragility of self-improving agents at COLM workshop — qinyuan_ye · 2026-10-04
- How one ellipsoid-fitting paper gave neural network research a new path — KyleCranmer · 2026-10-04
- 52,946 clinician-patient dialogues analyzed with NLP: 74% negative around diagnostic uncertainty — realmeetjames · 2026-10-04
- Blog traces AI's evolution from perceptron to Sora with linked papers — abhishekkumar333 · 2026-10-04
- ENCODE4 Preprint Maps 16,000+ Genome-Wide Experiments, Seeks Community Feedback — anshulkundaje · 2026-10-04
- AI code generation hits inflection point as synthetic data opportunities outpace ability to exploit them — mrjonfinger · 2026-10-04