Protein design challenge ups ante: pH-dependent EGFR binders with mouse cross-reactivity
nc_frey · x · 2026-09-29
- A new protein design competition (with Adaptyv) unveils its first challenge: targeting EGFR again, but demanding far more — a binder that is mouse cross-reactive and binds conditionally at acidic pH (tumor microenvironment) but not neutral pH.
- This sits at the frontier of current protein design capabilities and is a step toward therapeutically relevant performance; over 1,000 designs will be screened in the lab.
- The organizer's role is providing abundant Claude tokens, compute, and lab-testing budget so the world's best protein designers can attack the problem with their favorite models.
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