Kundaje tested Opus 5 and GPT6 on DNA motif annotation — both bad out of the box
anshulkundaje · x · 2026-09-24
- Stanford researcher Anshul Kundaje says the team hasn't had access to Mythos, but tried Opus 5 and GPT6 for DNA motif annotation and both were pretty bad out of the box.
- Supplementary note in the thread on genomic sequence annotation, underscoring that frontier LLMs can't yet handle this specialized multi-modal reasoning task without training.
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