Genome Language Model Minerva Uncovers a New Class of Reverse Transcriptase
JosephJacks_ · x · 2026-09-23
Researchers Garyk Brixi and David Li used genome language models to discover a new class of reverse transcriptase.
Their method, Minerva, is a discovery approach guided by genome language models. Genomes are full of "dark matter" of unknown function; Minerva reveals interactions hidden in non-coding DNA, pointing to hundreds of new putative RNAs and repetitive elements per bacterial genome, letting researchers find and study elements invisible to traditional methods at orders of magnitude greater scale than before.
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