Minerva mines the dark genome with genome language models
anshulkundaje · x · 2026-09-23
Stanford researchers released the Minerva preprint: coevolutionary mining with genome language models offers a scalable route to revealing the "dark genome" — training models on genomic sequences to predict specific functional and structural hypotheses.
- Core idea: compress the vast genomic sequence corpus into models that in turn help us understand genomes.
- The framework already points to large numbers of loci for follow-up, suggesting missing functional DNA and RNA across biology.
- RNA–protein interactions and long-range dependencies remain hard; next step is extending Minerva to eukaryotic genomes.
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