OXtalign: open-source crystal-packing similarity tool up to 200x faster than COMPACK

CatAstro_Piyush · x · 2026-09-22

The OXtal team released OXtalign, a fast open-source Python package (Apache 2.0, gemmi+numpy+scipy) for comparing crystal packings via the standard RMSDn metric from CCDC's COMPACK. On 2,000 CSD comparisons its RMSD values agree with COMPACK to 0.004 Å, match decisions agree on 99% of curated polymorph comparisons, and it runs up to 200x faster at 7.8 ms per comparison on one core. Built by ChengHao Liu, last author of OXtal.

Original post →

More from Research

Research channel →