BindCraft2 Drops Early: AF2-Centric Protein Design Code Free for All, No Paper Wait
AllThingsApx · x · 2026-09-21
Martin Pacesa announced BindCraft2, releasing the full code immediately and free for both academic and industry use — ahead of the paper — so researchers can start designing right away and apply it to the current Adaptyv competition.
Key changes vs the original BindCraft:
- Drops the PyRosetta dependency in favor of an AlphaFold2 (AF2)-centric design-and-evaluation pipeline
- After design, candidates are re-predicted with a separate AF2 model and filtered using interface-confidence metrics like ipDAE
- Selection emphasizes reproducibility and plausibility of predicted binding modes rather than Rosetta ΔG scores
Related event: BindCraft2 Released: Code Open-Sourced Same Day, Free for Commercial Use(5 posts)→
More from Research
- 50+ NeurIPS 2025 papers found containing AI hallucinations that slipped past peer review — CSProfKGD · 2026-11-12
- Indie researcher pauses RNN training over environment bugs, shifts to FunSearch-style tasks — cephaloform · 2026-11-12
- Self-supervised visual similarity partially explains word generalization in humans and machines — Patricio M. Vera · 2026-11-12
- P2Echo: one text-prompted model segments multi-view echocardiography with high accuracy and low cost — UBC-V · 2026-11-12
- I Fixed Alamo Drafthouse's Search With Query Logs Alone: +18.4% MRR, No Model Training — CShorten30 · 2026-11-12
- NYU lab open-sources Outerloop: autonomous research agents that open PRs only when benchmarks improve — mengyer · 2026-11-12