Multimodal gene prioritization reveals nonlinear regulatory architecture in childhood-onset asthma
anshulkundaje · x · 2026-09-19
A UCSD team presented their childhood-onset asthma genomics work at APPG 2026 and posted a medRxiv preprint ahead of #ASHG2026. The study integrates large-scale GWAS, bulk-tissue transcriptomics, and single-cell regulatory data to prioritize disease-relevant genes and cellular contexts, revealing a nonlinear regulatory architecture and improving cross-cohort polygenic risk prediction. Authors: Nan Huang, Michelle F. Ragsac, Xiaoyu Gui, Kelan G. Tantisira, Tiffany Amariuta.
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