Researchers argue aggregate variant effect models already enable ALS therapeutic discovery
anshulkundaje · x · 2026-09-18
Stanford professor Anshul Kundaje argued that a single aggregate score is not optimal for variant prioritization. Genomics researcher Sai Zhang pushed back supportively: aggregate (AG) and S2F models are far more useful than many think — his team showed they can enable therapeutic discovery for ALS, and the field needs more such demonstrations.
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