Stanford team grows human brain organoids in mouse cortex in Nature xenocortication study
nathanbenaich · x · 2026-09-18
Sergiu Pașca's lab at Stanford, with co-authors including Karl Deisseroth and Ivan Soltesz, published an open-access Nature paper on developmental xenocortication: transplanting human stem-cell-derived cortical organoids into mouse brains.
Because human brain tissue is largely inaccessible, stem-cell organoids are the main route to studying human neural development. This work integrates human organoids with mouse cortex in vivo, offering a new paradigm for studying human neuronal development and circuit function. The paper has already drawn 925 Altmetric attention.
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