Context-specific non-coding effects vs coding-only clinical guidelines
anshulkundaje · x · 2026-09-18
- Non-coding variant effects are highly cell-context specific, a weakness for DNA LMs not conditioned on cell context.
- Clinical prioritization guidelines meanwhile focus almost exclusively on protein-coding variants.
Related event: Stanford Expert's Deep Dive on DeepMind's AlphaGenome AVI Score(29 posts)→
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