Aggregate variant scores like CADD still useful when paired with context-specific effects
anshulkundaje · x · 2026-09-18
- Aggregate scores (CADD, AVI, GPN-STAR, etc.) remain useful when coupled with context-specific measured or predicted effects across diverse molecular mechanisms, though these ideas are still nascent.
- The rise of AI agents and model interpretation now offers opportunities to avoid lossy summarization and reason directly over multi-dimensional variant effect scores.
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