Prime assembly: Nature paper shows CRISPR-based in-cell integration of gene-sized DNA fragments
AllThingsApx · x · 2026-09-17
A team led by Daniel E. Bauer published an open-access Nature paper describing prime assembly, a Gibson-cloning-inspired method that leverages CRISPR-targeted dual flap synthesis to assemble and integrate gene-sized DNA fragments directly in human cells, including targeted genomic rearrangements.
The work tackles a core challenge in therapeutic genome editing: installing medium-to-large genomic modifications in therapeutically relevant cells, with potential implications for treating inherited and acquired disorders.
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