Single-cell mass spec (plexDIA) quantifies more gene products per cell than RNA measurements

iskander · x · 2026-09-16

A thread shared by the Slavov lab reports that single-cell mass spectrometry via plexDIA quantified more protein-coding gene products per cell than RNA-based measurements, with substantially higher data completeness. The consistency and quantification accuracy now make it possible to ask a challenging question: how do gene products co-vary from cell to cell within the same cell type?

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