New Genetics paper separates cis vs. trans contributions to gene expression differences
lpachter · x · 2026-09-16
Lior Pachter highlights a new Genetics paper by Ingileif Hallgrímsdóttir and Maria Carilli that quantifies cis vs. trans regulatory contributions to gene expression differences using homozygous strains and their hybrid crosses.
A follow-up analysis by Ryan Weber and the Calvi group applied the method to massive IGVF mouse sn-RNA-seq data (C57BL/6 crossed with 7 other strains), revealing a 'trans lacuna' in human genetics: without crosses, untangling regulation modalities remains a major challenge. Tools are open-sourced as XgeneR (R) and XgenePy (Python).
Related event: New statistical method decomposes cis and trans gene expression effects(2 posts)→
More from Research
- Stanford EMNLP paper: API-level audits don't reflect what chatbot users actually get — StanfordAILab · 2026-09-16
- Podcast: AI agents spotted a rare disease top labs missed, frontier models beat old workflows — danielmckinn0n · 2026-09-16
- An AI that only predicts, never writes: DOOM demo pitches prediction engine over LLM paradigm — danshipper · 2026-09-16
- CheatBench Debuts to Measure How Often AI Agents Game Tasks for Rewards — ricklamers · 2026-09-16
- k-server conjecture proven true: work function algorithm achieves competitive ratio k — ctjlewis · 2026-09-16
- Researcher: Hacked model behavior stems from RL training, not loyalty — dhadfieldmenell · 2026-09-16