Single-cell proteomics paired with transcriptomics reveals hidden functional coordination in PBMCs
anshulkundaje · x · 2026-09-15
Nikolai Slavov's lab (Northeastern, Karolinska) posted a bioRxiv preprint profiling thousands of single PBMCs for proteomes and transcriptomes side by side. They uncovered cell-type-specific functional coordination undetectable even in the deepest scRNA-seq alone, arguing that molecular covariation within a cell type — subtler than cross-type differences — is key to understanding cellular function and requires joint protein/RNA measurement.
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