Biologists push back: AlphaFold useful in some cases but weak on out-of-distribution proteins

lpachter · x · 2026-09-13

A debate over AlphaFold's real capabilities: responding to a joke about biologists embracing the black box while mathematicians nitpick, MathSRIsh argues the take is wrong and fuels lay overestimation. Biologists have carefully evaluated AlphaFold versions and found them useful in some cases but severely lacking for most out-of-distribution proteins.

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