Opus Refuses Protein Research Codebase Over 'Safety' Concerns, Dev Considers Rolling His Own
josephdviviano · x · 2026-09-11
A developer reports that Claude Opus has refused for two days to touch their research protein-generation codebase in any way — even writing SLURM job launcher scripts — citing "safety" concerns. They suspect it's a bug that will be fixed within a week, but with time being money, are considering rolling their own solution. The case highlights how safety guardrails can misfire on legitimate scientific workloads.
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