96-plasmid yeast transformation in 3.25 hours with open-source Pylabrobot
nlarusstone · x · 2026-09-06
Genetic Assemblies demoed a 96-plasmid yeast transformation plus 384-spot clonal plating across 4 SBS agar plates, completed in 3.25 hours using the open-source lab automation framework Pylabrobot. The post also links to their RFC series covering bioautomation, conjugation-based transfection, Nanopore in-process validation and a 'Plasmid Factory' pipeline, arguing general automation beats bespoke automation in synthetic biology.
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