NVIDIA Parabricks HaplotypeCaller lands in nf-core/sarek for GPU-accelerated germline calling

AllThingsApx · x · 2026-09-04

NVIDIA announced that Parabricks HaplotypeCaller is now available in nf-core/sarek (v3.10.0), a widely adopted germline analysis pipeline.

• nf-core/sarek detects germline or somatic variants from WGS/targeted sequencing data, covering pre-processing, variant calling, and annotation; it's built on Nextflow with containerized, reproducible processes and works with any species with a reference genome.
• Sarek previously offered Parabricks-accelerated alignment; this update extends GPU acceleration to germline variant calling via HaplotypeCaller.
• The release is available now on nf-co.re, continuing NVIDIA's push of GPU acceleration into standard open-source genomics workflows.

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