NEJM: Single-Dose In-Vivo B-Cell Depletion Helps All 16 Refractory Autoimmune Patients
EricTopol · x · 2026-09-03
Eric Topol highlights a NEJM study on in-vivo B-cell depletion for refractory autoimmune neurologic conditions: all 16 patients — including 7 with progressive multiple sclerosis — showed clinical and biologic improvement after a single dose using an off-the-shelf lentiviral vector. The approach bypasses the complicated, laborious ex-vivo methods used until now, advancing B-cell depletion from a complex procedure toward a potentially curative, scalable option for autoimmune disease.
More from Research
- Opus-assisted open design: a $31k low-field head MRI sketched in hours — DreamFly_13 · 2026-10-18
- semiconductor.diy: open-source guides to make real chips in a garden shed — jwt0625 · 2026-10-18
- Work in progress: geometric structure of GPG projections as Markov chain coarsening — michaelchchoi · 2026-10-18
- Backprop-free pretraining gets 2.3x speedup as Noise method crushes Dust record on 8 GPUs — inductionheads · 2026-10-18
- q3dviewer: open-source Qt+OpenGL tool for painter-like point cloud editing — 4310sy · 2026-10-18
- Smarter Every Day's Destin to defend PhD dissertation on impact fusion — CatAstro_Piyush · 2026-10-18