TiDE-Ab paper introduces time-dependent guidance for antibody design
DaveJuergens · x · 2026-08-25
Published in Bioinformatics (ECCB 2026), this paper addresses a trade-off in therapeutic antibody design: strong guidance improves epitope targeting but distorts the structure and causes steric clashes.
Core Method (TiDE-Ab):
- Implements time-dependent guidance: strong during global binding pose formation, then decaying to zero.
- Effect: Allows CDR loops to settle into clean local geometry.
Results: Precision recovered to 0.889 from 0.777 at the same epitope recall, significantly reducing structural clashes.
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