How to choose between LangGraph, CrewAI, AutoGen, OpenAI Agents SDK and LlamaIndex
goyalshaliniuk · x · 2026-08-22
A thread comparing 5 popular AI agent frameworks and when to use each:
- LangGraph: complex, stateful agents needing memory, branching workflows and human-in-the-loop; fine-grained production control
- CrewAI: multi-agent teams of specialized agents for research, content creation and role-based workflows
- OpenAI Agents SDK: lightweight apps with tools, handoffs, guardrails and tracing; provider-agnostic with 100+ LLMs
- AutoGen: agent-to-agent experimentation and prototyping (note: now in maintenance mode; Microsoft recommends migrating to Agent Framework)
- LlamaIndex: agents working heavily with documents, databases, APIs and private knowledge (RAG-centric)
Key advice: don't pick a framework because it's trending — pick based on the problem your agent needs to solve.
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