Debunked: AI didn't invent a cancer vaccine overnight — it picks neoantigens

GaryMarcus · x · 2026-08-20

Viral claims that "AI suddenly discovered a cancer vaccine" are engagement bait. Moderna and Merck reported positive Phase 3 results for Intismeran plus Keytruda in 1,137 post-surgery melanoma patients — a real and important result.

But the vaccine entered human trials in 2017, and AI/bioinformatics was used to analyze mutations and select up to 34 neoantigens per patient for the personalized treatment — it did not independently invent the vaccine or cure cancer. Full Phase 3 numbers are unreleased, overall survival is unknown, the treatment is unapproved, and it was tested with Keytruda, not alone. BioNTech, Roche, NEC, Transgene and Evaxion have used similar ML approaches for years.

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