NVIDIA's Proteina-Complexa enables agents to discover sub-nanomolar protein binders
AllThingsApx · x · 2026-08-19
NVIDIA's Proteina-Complexa framework, used within Manifold Bio's autonomous research pipeline, successfully produced sub-nanomolar binders for TREM2, topping the leaderboard.
Key Highlights of Proteina-Complexa:
- Unifies conditional generative modeling and optimization for atomistic protein binder design.
- No Redesign: Generates binder sequences end-to-end without inverse folding.
- Test-Time Scaling: Increased compute at inference leads to better binders.
- Wet Lab Validation: Screened >1M candidates for 133 targets with hit rates up to 63.5% and picomolar affinities.
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