Nature paper: Epigenetic drift in microglia drives aging
rand_longevity · x · 2026-08-19
Rand Longevity shared a Nature Neuroscience paper confirming that epigenetic drift is a major driver of aging. The study shows that aging brain cells lose epigenetic control, leading to the derepression of endogenous retroviruses, which activates microglia and causes inflammation and senescence. The author suggests that restoring youthful epigenetic control could reverse aspects of the aging phenotype.
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