Nature Study: 40% of fMRI Signals May Be Misleading, BOLD Opposes Metabolism in Default Mode Network
MacrinePhD · x · 2026-08-15
A study published in Nature Neuroscience reveals that standard fMRI's BOLD signal moves opposite to metabolic activity in key regions like the default mode network, with about 40% of significant BOLD changes showing reversed oxygen metabolism. This raises questions about decades of brain mapping. Published Dec 16, 2025, with 82k accesses and 42 citations.
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