Expert questions scalability of single-cell data for AI training, citing lack of counterfactual predictive power

anshulkundaje · x · 2026-08-06

Anshul Kundaje discusses single-cell perturbation data (scPerturb), stating he has not seen convincing evidence that it is the right modality to scale for training AI models with decent counterfactual predictive capability in high-impact downstream applications like in vivo, drug discovery, and clinical trials. He clarifies that scPerturb data is not useless; it is useful for many analyses, but exceptions might be immune cell types and a few other systems.

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