Reconstructing >1.5M Cells: Mouse Embryonic Lineage Atlas Released
anshulkundaje · x · 2026-08-01
Researchers have released the Mouse Embryonic Lineage Atlas (MELA), reconstructing single-cell lineages using DNA Typewriter technology.
- Scale: Profiles over 1.5 million cells across 16 mouse embryos staged from E7.5 to E10.0.
- Technology: By continuously installing heritable genetic marks, the team reconstructed lineage trees resolving 75% of cell divisions.
- Insights: Paired with transcriptional profiling, the data quantifies fate biases and reveals strikingly reproducible lineage architecture despite developmental flexibility.
The dataset is open source and interactive via the CELLxLINEAGE platform, providing a reference for cell fate specification.
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