Fine-Tuning AlphaGenome's Splicing Heads from Scratch: A Genomics Workflow
arjunrajlab · x · 2026-07-30
The CRG research team shared how they fine-tuned and evaluated AlphaGenome's splicing heads from scratch, aiming to develop a workflow that adapts the model to new RNA-seq samples.
Using a sample carrying the SF3B1 K700E cancer-driver mutation as a case study, the post details the complete pipeline covering data preprocessing, loading, debugging, and testing on held-out genomic intervals.
Related event: Team Fine-Tunes AlphaGenome for RNA-seq Data Adaptation(4 posts)→
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