A 2023 bioML recipe with wet-lab validation may reduce exposure bias in sequence design
anshulkundaje · x · 2026-07-29
A bioML thread highlights a simple 2023 recipe with wet-lab validation that helps mitigate exposure bias in sequence design, and notes the method has since been replicated many times in related settings.
The attached figure shows the underlying problem framing: surrogate training points, out-of-distribution points, and the effect of the approach on the score landscape, making the discussion directly relevant to sequence-design workflows.
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